Osteosarcoma: Causes and Treatments

Ankle osteoarthritis is a condition that causes pain and stiffness in the ankle joint. Traditional treatments like joint fusion can limit mobility. An alternative procedure called ankle distraction arthroplasty has been gaining some traction, but how well does it hold up in the long term? 

A recent study by Greenfield et al. (2019) investigated this very question. They conducted a survival analysis of ankle distraction arthroplasty for ankle osteoarthritis. Their findings suggest that this procedure may be a viable option for some patients. 

Key takeaways from the study: 

  • Ankle distraction arthroplasty showed promising results, with an 84% survival rate at 5 years. This is better than some previously reported outcomes. 
  • The study also identified factors that can influence the success of the procedure. Avascular necrosis of the talus (bone death) was associated with a lower survival rate. Additionally, sex may play a role, with the study suggesting potential gender differences in long-term outcomes. 

What this means for patients: 

Ankle distraction arthroplasty offers a potential option for preserving joint mobility in patients with ankle osteoarthritis. This study provides valuable data for surgeons and patients to consider when making treatment decisions. 

Important to note: 

  • This was a retrospective study, meaning researchers analyzed past data. More robust research designs are needed to confirm these findings. 
  • The study involved a relatively small group of patients. Larger studies are necessary to draw more definitive conclusions. 

Overall, this research suggests that ankle distraction arthroplasty may be a valuable tool for treating ankle osteoarthritis. However, more research is needed to solidify its place as a standard treatment option. 

ReferenceGreenfield, S., Matta, K. M., McCoy, T. H., Rozbruch, S. R., & Fragomen, A. (2019). Ankle distraction arthroplasty for ankle osteoarthritis: a survival analysis. Strategies in trauma and limb reconstruction, 14(2), 65. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376580/#:~:text=In%20a%20significantly%20larger%20series,and%2037%25%20within%205%20years

Disclaimer:

This blog is for informational purposes only and should not be considered as medical advice. Always consult with a qualified healthcare professional to discuss your individual treatment options.
 

Image Credit: WebMD 

“Wellness is the complete integration of body, mind, and spirit – the realization that everything we do, think, feel, and believe has an effect on our state of well-being.” – Greg Anderson

Article Authors: Gordon Slater|Tandose Sambo 

Our musculoskeletal system is the framework of our entire being. It protects our soft inner organs, keeps us mobile, and supports our body weight. Osteosarcoma is a condition that affects the natural functioning mechanisms of our bones. This medical condition is defined as a type of bone cancer. Predominantly affecting the longer bones of the body, it is found to affect the leg bones the most. 

Symptoms of Osteosarcoma

The predominant symptoms for osteosarcoma include: 

  1. Painful sensations felt by the patient in the bone or joint
  2. Swelling near the affected site
  3. Weakness of bones. Patients can incur injuries or even fractures of the bone, due to its weakened state. 

How is Osteosarcoma diagnosed?

Osteosarcoma is diagnosed via medical assessment. As a condition that affects children and young adults, a visit to your orthopaedic specialist will help to identify if the cancer is present. Since many orthopaedic conditions have similar symptoms, it is often important to have medical tests such as biopsies done, in order to identify if osteosarcoma is present. Additionally, X-rays can provide a visual of the bone surface, so any abnormalities in bone development may be noted. 

What causes Osteosarcoma? 

While the medical community is still making an effort to understand what causes osteosarcoma, the root cause is identified to be in the mechanism of new bone formation. Healthy bone cells will have normal DNA as the code for the generation of new healthy cells. Studies have shown that in the case of osteosarcoma, the patient’s DNA is altered, so that abnormal cells are now being produced. Excessive generation of new bone is formed, and the ultimate result is the formation of a tumour. Osteosarcoma must be treated, in order to reduce any additional adverse health complications. These could include the spread of cancer through the body, limb amputation and side effects of cancer treatment. 

Novel Therapies for treating Osteosarcoma 

Traditional treatments for cancer include surgery, radiation and chemotherapy. These methods tend to be invasive treatments. With the advent of orthobiologics and gene editing technology, there are now new treatments being developed that help to treat osteosarcoma in a gentler, more natural way. There are currently attempts to incorporate the utilisation of the chimeric antigen receptor (CAR) as targeted immunotherapy against osteosarcoma (OS)[2]. The CAR-T cells are genetically modified cells that target and eliminate cancer cells in a patient. 

Natural progression of osteosarcoma can result in a life span of five additional years. With treatment included in a patient’s regimen, treatments such as chemotherapy are found to have improved the survival rate from 20% to 60% currently. Utilisation of CAR-T cell therapy aims to be the treatment that will take treatment of osteosarcoma to the next level. 

While much remains to be explored, once medical science can create CAR-T cells that target a specific critical site on the OS cells, and not impact normal tissues, the research will be successful. The results for the treatment of OS via CAR-T cell therapy seem to be promising, and leading us in the right direction for the development of clinical treatments. 

References:

[1] Mayo Clinic: Osteosarcoma 

[2] Pub Med: Treating Osteosarcoma with Car T Cells 

Like this article?

Share on Facebook
Share on Twitter
Share on Linkdin
Share on Pinterest

Dr. Gordon Slater

Dr. Slater is one of the first foot and ankle surgeons in Australia to adopt minimally invasive surgical techniques. He routinely uses MIS to treat a range of conditions, including bunions.

Leave a comment

Dr Gordon Slater is a highly-skilled surgeon specialising in foot and ankle conditions and sports injuries. Dr Slater is one of the first foot and ankle surgeons in Australia to adopt minimally invasive surgical techniques. He routinely uses MIS to treat a range of conditions, including bunions. MIS  has many advantages including shorter operating times, reduced post-operative pain, reduced risk of infection, minimal scarring and better cosmetic outcomes.

Copyright © 2022 orthopaedic-surgeon.com.au