Introduction
Psoriasis is a chronic autoimmune skin condition characterized by the rapid proliferation of skin cells, leading to thick, scaly patches that can cause discomfort and affect the quality of life. Traditional treatments encompass topical agents, phototherapy, systemic medications, and biologics. However, these treatments may not be effective for all patients and can have significant side effects. An emerging therapeutic approach is Hyperbaric Oxygen Therapy (HBOT), which has shown promise in managing various medical conditions, including psoriasis.[1]
Understanding Hyperbaric Oxygen Therapy (HBOT)
HBOT involves placing a patient in a pressurized chamber and administering 100% oxygen at elevated atmospheric pressures. This process increases the amount of oxygen dissolved in the body’s tissues, promoting healing and reducing inflammation. HBOT has been approved by the FDA for treating several conditions, such as decompression sickness, non-healing wounds, and certain infections. Its application in dermatological conditions like psoriasis is gaining attention due to its potential regenerative effects.[2]
HBOT and Psoriasis: Mechanisms of Action
The therapeutic effects of HBOT in psoriasis are thought to be multifaceted:
- Anti-inflammatory Effects: HBOT reduces pro-inflammatory cytokines, thereby diminishing the inflammatory response associated with psoriasis.
- Enhanced Wound Healing: By increasing oxygen delivery to tissues, HBOT accelerates the healing of psoriatic lesions.
- Modulation of Immune Response: HBOT may help in normalizing the hyperactive immune response seen in psoriasis, leading to a reduction in symptoms.
Clinical Evidence Supporting HBOT in Psoriasis
A study conducted by Slater and Bachmid explored the application of HBOT in treating psoriasis. The findings suggested that HBOT could serve as a viable adjunct therapy for psoriasis, offering benefits such as reduced lesion size and improved patient comfort. The non-invasive nature of HBOT also presents an advantage over more aggressive treatments.
Conclusion
While traditional therapies remain the cornerstone of psoriasis management, HBOT offers a promising adjunctive treatment option. Its ability to enhance oxygen delivery, reduce inflammation, and promote tissue regeneration positions it as a valuable tool in the comprehensive management of psoriasis. Further large-scale studies are warranted to fully establish its efficacy and optimal treatment protocols.
Disclaimer: This blog is for informational purposes only and should not be considered medical advice. Please consult with your healthcare provider for any questions or concerns regarding your individual health.
References
[1] G. Slater, “Hyperbaric Oxygen Therapy: An Overview,” Journal of Regenerative Biology and Medicine, Jun. 2022, doi: https://doi.org/10.37191/mapsci-2582-385x-4(3)-111
[2] G. Slater, “Application of HBOT in Treating Psoriasis,” Journal Of Regenerative Biology And Medicine, May 2024, doi: https://doi.org/10.37191/mapsci-2582-385x-5(6)-144
